Multimodal chemical imaging of a single brain tissue section using ToF-SIMS, MALDI-ToF and immuno/histochemical staining
Journal article, 2021

Cluster ion beam ToF-SIMS and/or MALDI-ToF mass spectrometry imaging (using 1,5-DAN matrix via sublimation) of a single coronal rat brain tissue section followed by classical-or immuno-histochemical staining faclilated a new multimodal chemical imaging workflow allowing complementary correlation of the lipid molecular ion images with the immuno/histological features within cerebellum region of the same brain tisue section.


Ibrahim Kaya

University of Gothenburg

Sahlgrenska University Hospital

Uppsala University

Gothenburg Imaging Mass Spectrometry (Go:IMS) Platform

Eva Jennische

University of Gothenburg

Stefan Lange

University of Gothenburg

Per Malmberg

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Gothenburg Imaging Mass Spectrometry (Go:IMS) Platform

The Analyst

0003-2654 (ISSN) 1364-5528 (eISSN)

Vol. 146 4 1169-1177

Subject Categories

Atom and Molecular Physics and Optics

Radiology, Nuclear Medicine and Medical Imaging

Medical Image Processing





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4/1/2021 1