Polymers in pharmaceutical additive manufacturing: A balancing act between printability and product performance
Review article, 2021

Materials and manufacturing processes share a common purpose of enabling the pharmaceutical product to perform as intended. This review on the role of polymeric materials in additive manufacturing of oral dosage forms, focuses on the interface between the polymer and key stages of the additive manufacturing process, which determine printability. By systematically clarifying and comparing polymer functional roles and properties for a variety of AM technologies, together with current and emerging techniques to characterize these properties, suggestions are provided to stimulate the use of readily available and sometimes underutilized pharmaceutical polymers in additive manufacturing. We point to emerging characterization techniques and digital tools, which can be harnessed to manage existing trade-offs between the role of polymers in printer compatibility versus product performance. In a rapidly evolving technological space, this serves to trigger the continued development of 3D printers to suit a broader variety of polymers for widespread applications of pharmaceutical additive manufacturing.

Characterization

Digitalization

Fused deposition modelling

Excipients

Quality by design

3D printing

Process analytical technology

Processability

Macromolecules

Oral drug delivery

Author

Rydvikha Govender

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Anette Larsson Group

Eric Ofosu Kissi

Nanoform Finland Oyj

University of Oslo

Anette Larsson

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Anette Larsson Group

Ingunn Tho

University of Oslo

Advanced Drug Delivery Reviews

0169-409X (ISSN)

Vol. 177 113923

New Instruments for Nordic University Cooperation: Nordic University Hubs (Nordic POP)

NordForsk (ProjectNo85352), 2018-01-01 -- 2023-12-31.

Subject Categories

Polymer Chemistry

Polymer Technologies

Textile, Rubber and Polymeric Materials

DOI

10.1016/j.addr.2021.113923

More information

Latest update

9/3/2021 2