Advances in the Relationships Between Cow’s Milk Protein Allergy and Gut Microbiota in Infants
Review article, 2021

Cow’s milk protein allergy (CMPA) is an immune response to cow’s milk proteins, which is one of the most common food allergies in infants and young children. It is estimated that 2–3% of infants and young children have CMPA. The diet, gut microbiota, and their interactions are believed to be involved in the alterations of mucosal immune tolerance, which might lead to the development of CMPA and other food allergies. In this review, the potential molecular mechanisms of CMPA, including omics technologies used for analyzing microbiota, impacts of early microbial exposures on CMPA development, and microbiota–host interactions, are summarized. The probiotics, prebiotics, synbiotics, fecal microbiota transplantation, and other modulation strategies for gut microbiota and the potential application of microbiota-based design of diets for the CMPA treatment are also discussed. This review not only summarizes the current studies about the interactions of CMPA with gut microbiota but also gives insights into the possible CMPA treatment strategies by modulating gut microbiota, which might help in improving the life quality of CMPA patients in the future.

cow’s milk allergy

fecal microbiota transplantation

synthetic microbiota



gut microbiota


Yudie Yang

Zhengzhou University

Xiaoqi Li

Zhengzhou University

Ying Yang

Fudan University

Saeed Shoaie

Royal Institute of Technology (KTH)

King's College London

Cheng Zhang

Zhengzhou University

Royal Institute of Technology (KTH)

Boyang Ji

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Yongjun Wei

Zhengzhou University

Frontiers in Microbiology

1664302x (eISSN)

Vol. 12 716667

Subject Categories

Other Engineering and Technologies not elsewhere specified

Interaction Technologies

Biomedical Laboratory Science/Technology



More information

Latest update