Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective
Review article, 2021
The concept of the exposome was introduced over 15 years ago to reflect the important role that the environment exerts on health and disease. While originally viewed as a call-to-arms to develop more comprehensive exposure assessment methods applicable at the individual level and throughout the life course, the scope of the exposome has now expanded to include the associated biological response. In order to explore these concepts, a workshop was hosted by the Gunma University Initiative for Advanced Research (GIAR, Japan) to discuss the scope of exposomics from an international and multidisciplinary perspective. This Global Perspective is a summary of the discussions with emphasis on (1) top-down, bottom-up, and functional approaches to exposomics, (2) the need for integration and standardization of LC- and GC-based high-resolution mass spectrometry methods for untargeted exposome analyses, (3) the design of an exposomics study, (4) the requirement for open science workflows including mass spectral libraries and public databases, (5) the necessity for large investments in mass spectrometry infrastructure in order to sequence the exposome, and (6) the role of the exposome in precision medicine and nutrition to create personalized environmental exposure profiles. Recommendations are made on key issues to encourage continued advancement and cooperation in exposomics.
Author
Pei Zhang
Gunma University
China Pharmaceutical University
Karolinska Institutet
Christopher Carlsten
University of British Columbia (UBC)
Romanas Chaleckis
Gunma University
Karolinska Institutet
Kati Hanhineva
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
University of Turku
University of Eastern Finland
Mengna Huang
Brigham and Women's Hospital
Tomohiko Isobe
National Institute for Environmental Studies of Japan
Ville Mikael Koistinen
University of Turku
University of Eastern Finland
Isabel Meister
Karolinska Institutet
Gunma University
Stefano Papazian
Stockholm University
Kalliroi Sdougkou
Stockholm University
Hongyu Xie
Stockholm University
Jonathan W. Martin
Stockholm University
Stephen M. Rappaport
University of California
Hiroshi Tsugawa
Tokyo University of Agriculture and Technology
Yokohama City University
RIKEN
Douglas I. Walker
Icahn School of Medicine at Mount Sinai
Tracey J. Woodruff
University of California
Robert O. Wright
Icahn School of Medicine at Mount Sinai
Craig E. Wheelock
Karolinska Institutet
Gunma University
Karolinska University Hospital
Environmental Science and Technology Letters
23288930 (eISSN)
Vol. 8 10 839-852Subject Categories
Ethics
Social Sciences Interdisciplinary
Other Social Sciences not elsewhere specified
DOI
10.1021/acs.estlett.1c00648
PubMed
34660833