Pregnancy outcomes with differences in grain consumption: a randomized controlled trial
Journal article, 2022

Objectives: Contemporary obstetrics has begun to appreciate the importance of diet in pregnancy, but guidelines are not based on robust data. The hypothesis that a whole grains diet improves pregnancy outcomes is tested in this study. We compared maternal and neonatal outcomes for a pregnancy diet containing 75% of total carbohydrates as refined grains with outcomes for a diet with 75% of total carbohydrates as whole grains. Methods: This was a randomized interventional study in a clinic population over the last 4-7 months of normal pregnancy with extensive compliance measures. Besides obstetrical and neonatal outcomes, anthropometric measurements were done. In addition to food frequency questionnaires (FFQs), total plasma alkyl resorcinols, a unique quantitative measure of whole grains, were used as a measure of whole grain consumption. Results: The data show effective compliance and no difference in outcomes between the diets with regard to maternal weight gain, birth weights, subcutaneous fat and glucose tolerance. Conclusions: Ensuring compliance to a proper pregnancy diet resulted in satisfactory weight gain and normal outcomes even when the proportion of whole grains consumed is only 25% of total carbohydrates. NCT03232762, Effects of Diet on Pregnancy Outcome and Child Obesity.

glucose tolerance

whole grains

interventional diet






Pamella Yamada

New York University

Alexandra Paetow

New York University

Michael Chan

New York University

Alan Arslan

New York University

Rikard Landberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Bruce K. Young

New York University

Journal of Perinatal Medicine

0300-5577 (ISSN) 1619-3997 (eISSN)

Vol. 50 4 411-418

Subject Categories

Food Science

Obstetrics, Gynecology and Reproductive Medicine

Nutrition and Dietetics





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3/7/2024 9