A randomized controlled trial of the effects of whole grains versus refined grains diets on the microbiome in pregnancy
Journal article, 2022

Dietary whole grain consumption has been postulated to have metabolic benefits. The purpose of this study was to compare a pregnancy diet containing 75% of total carbohydrates as refined grains with a diet of 75% of total carbohydrates as whole grains for pregnancy outcomes and effects on the microbiome. Gestational weight gain, glucose tolerance and newborn outcomes were measured on 248 enrolled compliant women from whom a subset of 103 women consented to give 108 vaginal and 109 anal swabs. The data presented here are limited to the patients from whom the vaginal and anal swabs were obtained in order to study the microbiome. A microbiome—16SrRNA survey—was characterized in these samples. Samples and measurements were obtained at the first obstetrical visit, before beginning a prescribed diet (T1—baseline) and after 17–32 weeks on the prescribed diet (T3). Food frequency questionnaires and total plasma alkylresorcinols were used as a measure of whole grain consumption. There were no dietary differences in maternal weight gain, birth weight, or glucose tolerance test. Mothers consuming the whole grains diet showed a trend of gestational decrease in vaginal bacterial alpha diversity, with increasing Lactobacillus-dominance. No significant difference was observed for the anal microbiome. The results suggest that diet modulations of the vaginal microbiome during gestation may have important implications for maternal and neonatal health and in the intergenerational transfer of maternal microbiome. Trial registration: ClinicalTrials.gov Identifier: NCT03232762.


Haipeng Sun

Rutgers University

Pamella Yamada

NYU Langone Health

Alexandra Paetow

NYU Langone Health

Michael Chan

NYU Langone Health

Alan Arslan

NYU Langone Health

Rikard Landberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Maria Gloria Dominguez-Bello

Rutgers University

Bruce K. Young

NYU Langone Health

Scientific Reports

2045-2322 (ISSN) 20452322 (eISSN)

Vol. 12 1 7509

Subject Categories

Food Science

Obstetrics, Gynecology and Reproductive Medicine

Nutrition and Dietetics





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