A Molybdenum Disulfide Nanozyme with Charge-Enhanced Activity for Ultrasound-Mediated Cascade-Catalytic Tumor Ferroptosis
Journal article, 2023
The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. Since electron transfer is the basic essence of catalysis-mediated redox reactions, we explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS2@CA) is presented that is made from few-layer MoS2 nanosheets grown on the surface of piezoelectric tetragonal barium titanate (T-BTO) and modified with pH-responsive cinnamaldehyde (CA). The integration of pH-responsive CA-mediated H2O2 self-supply, ultrasound-mediated charge-enhanced enzymatic activity, and glutathione (GSH) depletion enables out-of-balance redox homeostasis, leading to effective tumor ferroptosis with minimal side effects.
Tumor Therapy
Nanozymes
Ferroptosis
Reactive Oxygen Species
Author
Longwei Wang
Northwest University
Chinese Academy of Sciences
Xiaodi Zhang
Jinan University
Zhen You
Northwest University
Chinese Academy of Sciences
Zhongwei Yang
Jinan University
Mengyu Guo
Chinese Academy of Sciences
Jia Wei Guo
Jinan University
He Liu
Chinese Academy of Sciences
Xiaoyu Zhang
Chinese Academy of Sciences
Northwest University
Zhuo Wang
Chinese Academy of Sciences
Aizhu Wang
Jinan University
Yawei Lv
Hunan University
Jian Zhang
Chalmers, Life Sciences, Systems and Synthetic Biology
Xin Yu
Jinan University
Jing Liu
Chinese Academy of Sciences
Northwest University
Chunying Chen
Chinese Academy of Sciences
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 62 11 e202217448Subject Categories
Basic Medicine
Physical Sciences
Biological Sciences
Chemical Sciences
DOI
10.1002/anie.202217448
PubMed
36585377