Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women.
Journal article, 2004
Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a single nucleotide polymorphism (G331A) and an insertion/deletion polymorphism (PROGINS) were investigated in 72 patients with panic disorder and 452 controls. The frequency of the A-allele of the G331A polymorphism was higher in panic disorder patients than in controls (p = 0.01). When male and female patients were analyzed separately, the association was observed in female patients only (p = 0.0009), with an odds ratio of 3.5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women.
Genetic Predisposition to Disease
Receptors
Progesterone
genetics
Risk Factors
Female
Male
genetics
genetics
Sex Factors
Polymorphism
Human
Pair 11
Humans
Single Nucleotide
Panic Disorder
genetics
Gene Frequency
Chromosomes
Author
Hoi-Por Ho
University of Gothenburg
Lars Westberg
University of Gothenburg
Kristina Annerbrink
University of Gothenburg
Marie Olsson
University of Gothenburg
Jonas Melke
University of Gothenburg
Staffan Nilsson
University of Gothenburg
Chalmers, Department of Mathematical Statistics
Fariba Baghaei
University of Gothenburg
Roland Rosmond
University of Gothenburg
Göran Holm
University of Gothenburg
Per Björntorp
University of Gothenburg
Sven Andersch
University of Gothenburg
Christer Allgulander
Karolinska Institutet
Elias Eriksson
University of Gothenburg
Psychoneuroendocrinology
0306-4530 (ISSN)
Vol. 29 9 1138-41Subject Categories
MEDICAL AND HEALTH SCIENCES
DOI
10.1016/j.psyneuen.2004.01.005
PubMed
15219637