Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women.
Artikel i vetenskaplig tidskrift, 2004
Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a single nucleotide polymorphism (G331A) and an insertion/deletion polymorphism (PROGINS) were investigated in 72 patients with panic disorder and 452 controls. The frequency of the A-allele of the G331A polymorphism was higher in panic disorder patients than in controls (p = 0.01). When male and female patients were analyzed separately, the association was observed in female patients only (p = 0.0009), with an odds ratio of 3.5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women.
Genetic Predisposition to Disease
Receptors
Progesterone
genetics
Risk Factors
Female
Male
genetics
genetics
Sex Factors
Polymorphism
Human
Pair 11
Humans
Single Nucleotide
Panic Disorder
genetics
Gene Frequency
Chromosomes
Författare
Hoi-Por Ho
Göteborgs universitet
Lars Westberg
Göteborgs universitet
Kristina Annerbrink
Göteborgs universitet
Marie Olsson
Göteborgs universitet
Jonas Melke
Göteborgs universitet
Staffan Nilsson
Göteborgs universitet
Chalmers, Institutionen för matematisk statistik
Fariba Baghaei
Göteborgs universitet
Roland Rosmond
Göteborgs universitet
Göran Holm
Göteborgs universitet
Per Björntorp
Göteborgs universitet
Sven Andersch
Göteborgs universitet
Christer Allgulander
Karolinska Institutet
Elias Eriksson
Göteborgs universitet
Psychoneuroendocrinology
0306-4530 (ISSN)
Vol. 29 9 1138-41Ämneskategorier
MEDICIN OCH HÄLSOVETENSKAP
DOI
10.1016/j.psyneuen.2004.01.005
PubMed
15219637