A different approach to enantioselective organic synthesis: absolute asymmetric synthesis of organometallic reagents.
Journal article, 2009
Voilà, optical activity: Both enantiomers of 1-chloroindene have been synthesized in high selectivity from solely achiral starting materials, and without using optically active catalysts (see scheme). These symmetry-breaking syntheses provide a proof-of-concept for a new approach to asymmetric synthesis. NCS=N-chlorosuccinimide.
chemistry
chemical synthesis
Organometallic Compounds
Stereoisomerism
Indenes
chemical synthesis
Author
Anders Lennartsson
University of Gothenburg
Susanne Olsson
University of Gothenburg
Jonas Sundberg
University of Gothenburg
Mikael Håkansson
University of Gothenburg
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 48 17 3137-40Subject Categories
Chemical Sciences
DOI
10.1002/anie.200806222
PubMed
19322856