Prototype gastro-resistant soft gelatin films and capsules-imaging and performance in vitro
Journal article, 2020

The following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer films was performed. The results suggest that the critical feature behind formation of the acid-resistant films is a spinodal decomposition in the film-forming mixture. In the obtained films, upon submersion in an acidic medium, gelatin swells and dissolves, exposing a CAP-based acid-insoluble skeleton, partially coated by a residue of other ingredients. The dissolution-hindering effect appears to be stronger when iota-carrageenan is added to the film-forming mixture. The drug release study performed in enhancer cells confirmed that diclofenac sodium is not released in the acidic medium, however, at pH 6.8 the drug release occurs. The capsules prepared with a simple lab-scale process appear to be resistant to disintegration of the shell structure in acid, although imperfections of the sealing have been noticed.

Films

Gastro-resistant

Drug release

Capsules

Structure

Gelatin

Author

Bartosz Maciejewski

Medical University of Gdańsk

Vishnu Arumughan

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Anette Larsson Group

Anette Larsson

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Anette Larsson Group

Małgorzata Sznitowska

Medical University of Gdańsk

Materials

1996-1944 (ISSN)

Vol. 13 7 1771

Subject Categories

Polymer Chemistry

Other Chemistry Topics

Studies on Film

DOI

10.3390/ma13071771

PubMed

32283855

More information

Latest update

7/15/2020