Self-assembled monolayer coating for normalization of surface enhanced Raman spectra
Artikel i vetenskaplig tidskrift, 2004

We demonstrate that the use of a self-assembled monolayer, consisting of a thiol derivative of Dabcyl, can be used to normalize surface enhanced Raman signals (SERS) with respect to varying enhancement. Chaotic assemblies of gold nanoparticles exhibit large spatial variation in enhancement. Our work shows that in such a system the signals from the reporting molecules in the SAM co-vary with the signal from the analyte solution. With this knowledge, a normalization procedure was used to increase the precision of the analyte signal by 1 order of magnitude, to 8-13%, fully acceptable for quantitative work.

normalization

surface enhanced Raman spectrocopy

SAM

gold nanoparticle

PCA

self-assembled monolayer

principal components analysis

SERS

Författare

Anders Lorén

Chalmers, Institutionen för kemi och biovetenskap, Analytisk och marin kemi

Johan Engelbrektsson

Chalmers, Institutionen för kemi och biovetenskap, Analytisk och marin kemi

Charlotte Eliasson

Chalmers, Institutionen för kemi och biovetenskap, Analytisk och marin kemi

Mats Josefson

AstraZeneca AB

Jonas Abrahamsson

Göteborgs universitet

Katarina Abrahamsson

Chalmers, Institutionen för kemi och biovetenskap, Analytisk och marin kemi

Nano Letters

1530-6984 (ISSN) 1530-6992 (eISSN)

Vol. 4 309-312

Ämneskategorier

Analytisk kemi

Kemi

DOI

10.1021/nl035064x