Cadmium, mercury, and lead in kidney cortex of living kidney donors: Impact of different exposure sources.
Artikel i vetenskaplig tidskrift, 2010

BACKGROUND: Most current knowledge on kidney concentrations of nephrotoxic metals like cadmium (Cd), mercury (Hg), or lead (Pb) comes from autopsy studies. Assessment of metal concentrations in kidney biopsies from living subjects can be combined with information about exposure sources like smoking, diet, and occupation supplied by the biopsied subjects themselves. OBJECTIVES: To determine kidney concentrations of Cd, Hg, and Pb in living kidney donors, and assess associations with common exposure sources and background factors. METHODS: Metal concentrations were determined in 109 living kidney donors aged 24-70 years (median 51), using inductively coupled plasma-mass spectrometry (Cd and Pb) and cold vapor atomic fluorescence spectrometry (Hg). Smoking habits, occupation, dental amalgam, fish consumption, and iron stores were evaluated. RESULTS: The median kidney concentrations were 12.9microg/g (wet weight) for cadmium, 0.21microg/g for mercury, and 0.08microg/g for lead. Kidney Cd increased by 3.9microg/g for a 10 year increase in age, and by 3.7microg/g for an extra 10 pack-years of smoking. Levels in non-smokers were similar to those found in the 1970s. Low iron stores (low serum ferritin) in women increased kidney Cd by 4.5microg/g. Kidney Hg increased by 6% for every additional amalgam surface, but was not associated with fish consumption. Lead was unaffected by the background factors surveyed. CONCLUSIONS: In Sweden, kidney Cd levels have decreased due to less smoking, while the impact of diet seems unchanged. Dental amalgam is the main determinant of kidney Hg. Kidney Pb levels are very low due to decreased exposure.

Middle Aged

Kidney Transplantation

Lead

Body Burden

drug effects

Cadmium

pharmacokinetics

Aged

pathology

Biopsy

Humans

Spectrophotometry

Kidney Cortex

analysis

Male

pharmacokinetics

Living Donors

standards

Smoking

toxicity

analysis

Adult

toxicity

Atomic

Female

pharmacokinetics

Environmental Exposure

Young Adult

Mercury

toxicity

analysis

Age Factors

Diet

metabolism

analysis

Författare

Lars Barregård

Göteborgs universitet

Elisabeth Fabricius-Lagging

Göteborgs universitet

Thomas Lundh

Johan Mölne

Göteborgs universitet

Maria Wallin

Göteborgs universitet

Michael Olausson

Göteborgs universitet

Cecilia Modigh

Göteborgs universitet

Gerd Sallsten

Göteborgs universitet

Environmental Research

0013-9351 (ISSN) 1096-0953 (eISSN)

Vol. 110 47-54

Ämneskategorier

Klinisk medicin

Cell- och molekylärbiologi

Miljömedicin och yrkesmedicin

DOI

10.1016/j.envres.2009.10.010

PubMed

19931045