Deformation of adsorbed lipid vesicles as a function of vesicle size
Artikel i vetenskaplig tidskrift, 2010

Experimental indications that adsorbed lipid vesicles arc deformed on the surface (e.g., oil SiO(2)) and that the deformation seems to be more pronounced for larger vesicles have been reported. In general. it has been assumed that larger vesicles should,how a stronger tendency for spontaneous rupture, which is also backed up by thermodynamic considerations (Seifert, U.; Lipowsky, R. PhYs. Rev. A 1990,42,4768; Seifert, U. Adv. PhYs. 1997, 46, 13). However, using a newly developed model of a lipid bilayer, simulations were performed to study the shape of adsorbed lipid vesicles for different vesicle sizes, with the observation that larger vesicles indeed are more deformed on the surface, but that there is no additional tendency for larger vesicles to rupture spontaneously. It is shown here that the radius of curvature, on the portions of the vesicle membrane that are most strained. is practically independent of the vesicle size. A kinetic barrier for vesicle rupture is proposed to be the reason for the observed disagreement with thermodynamic theory.

Monte Carlo simulation

Supported lipid bilayer

vesicle adsorption

vesicle rupture

vesicle deformation

lipid vesicle

bilayer model

Författare

Kristian Dimitrievski

Chalmers, Teknisk fysik, Kemisk fysik

Langmuir

0743-7463 (ISSN) 1520-5827 (eISSN)

Vol. 26 5 3008-3011

Ämneskategorier

Atom- och molekylfysik och optik

DOI

10.1021/la904743d

Mer information

Skapat

2017-10-07