Impact of yeast systems biology on industrial biotechnology
Artikel i vetenskaplig tidskrift, 2009

Systems biology is yet an emerging discipline that aims to quantitatively describe and predict the functioning of a biological system. This nascent discipline relies on the recent advances in the analytical technology (such as DNA microarrays, mass spectromety. etc.) to quantify cellular characteristics (such as gene expression, protein and metabolite abundance, etc.) and computational methods to integrate information from these measurements. The model eukaryote, Saccharomyces cerevisiae, has played a pivotal role in the development of many of these analytical and computational methods and consequently is the biological system of choice for testing new hypotheses. The knowledge gained from such studies in S. cerevisiae is proving to be extremely useful in designing metabolism that is targeted to specific industrial applications. As a result, the portfolio of products that are being produced using this yeast is expanding rapidly. We review the recent developments in yeast systems biology and how they relate to industrial biotechnology. (C) 2009 Elsevier B.V. All rights reserved.

Saccharomyces cerevisiae

gene-expression

flux analysis

functional genomics

saccharomyces-cerevisiae

Industrial biotechnology

Metabolic engineering

scale metabolic model

protein microarray technology

transcription machinery

dna

Systems biology

minimum information

microarray

mass-spectrometry

Författare

Dina Petranovic Nielsen

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Goutham Vemuri

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Journal of Biotechnology

0168-1656 (ISSN)

Vol. 144 3 204-211

Ämneskategorier

Industriell bioteknik

DOI

10.1016/j.jbiotec.2009.07.005