Gender-related long-term effects in adult rats by perinatal dietary ratio of n-6/n-3 fatty acids.
Artikel i vetenskaplig tidskrift, 2005

Epidemiological studies in humans have shown that perinatal nutrition affects health later in life. We have previously shown that the ratio of n-6 to n-3 polyunsaturated fatty acids (PUFA) in the maternal diet affects serum leptin levels and growth of the suckling pups. The aim of the present study was to investigate the long-term effects of various ratios of the dietary n-6 and n-3 PUFA during the perinatal period on serum leptin, insulin, and triacylglycerol, as well as body growth in the adult offspring. During late gestation and throughout lactation, rats were fed an isocaloric diet containing 7 wt% fat, either as linseed oil (n-3 diet), soybean oil (n-6/n-3 diet), or sunflower oil (n-6 diet). At 3 wk of age, the n-6/n-3 PUFA ratios in the serum phospholipids of the offspring were 2.5, 8.3, and 17.5, respectively. After weaning, all pups were given a standard chow. At the 28th postnatal wk, mean body weight and fasting insulin levels were significantly increased in the rats fed the n-6/n-3 diet perinatally compared with the other groups. The systolic blood pressure and serum triacylglycerol levels were only increased in adult male rats of the same group. These data suggest that the balance between n-6 and n-3 PUFA during perinatal development affects several metabolic parameters in adulthood, especially in the male animals.

pharmacology

administration & dosage

Fasting

Drug

Prenatal Exposure Delayed Effects

Animals

Male

Omega-6

blood

Phospholipids

pharmacology

Time Factors

Aging

Sex Factors

Fatty Acids

administration & dosage

Pregnancy

Female

blood

blood

Dose-Response Relationship

Fatty Acids

Rats

blood

Insulin

blood

blood

Animals

Fetus

Diet

Sprague-Dawley

Rats

Fatty Acids

Triglycerides

Cholesterol

Omega-3

Newborn

blood

Författare

Marina Korotkova

Göteborgs universitet

Britt Gabrielsson

Göteborgs universitet

Agneta Holmäng

Göteborgs universitet

Britt-Mari Larsson

Göteborgs universitet

Lars Åke Hanson

Göteborgs universitet

Birgitta Strandvik

Göteborgs universitet

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

0363-6119 (ISSN) 1522-1490 (eISSN)

Vol. 288 3 R575-9

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1152/ajpregu.00342.2004

PubMed

15699360