Gender-related long-term effects in adult rats by perinatal dietary ratio of n-6/n-3 fatty acids.
Artikel i vetenskaplig tidskrift, 2005
Epidemiological studies in humans have shown that perinatal nutrition affects health later in life. We have previously shown that the ratio of n-6 to n-3 polyunsaturated fatty acids (PUFA) in the maternal diet affects serum leptin levels and growth of the suckling pups. The aim of the present study was to investigate the long-term effects of various ratios of the dietary n-6 and n-3 PUFA during the perinatal period on serum leptin, insulin, and triacylglycerol, as well as body growth in the adult offspring. During late gestation and throughout lactation, rats were fed an isocaloric diet containing 7 wt% fat, either as linseed oil (n-3 diet), soybean oil (n-6/n-3 diet), or sunflower oil (n-6 diet). At 3 wk of age, the n-6/n-3 PUFA ratios in the serum phospholipids of the offspring were 2.5, 8.3, and 17.5, respectively. After weaning, all pups were given a standard chow. At the 28th postnatal wk, mean body weight and fasting insulin levels were significantly increased in the rats fed the n-6/n-3 diet perinatally compared with the other groups. The systolic blood pressure and serum triacylglycerol levels were only increased in adult male rats of the same group. These data suggest that the balance between n-6 and n-3 PUFA during perinatal development affects several metabolic parameters in adulthood, especially in the male animals.
pharmacology
administration & dosage
Fasting
Drug
Prenatal Exposure Delayed Effects
Animals
Male
Omega-6
blood
Phospholipids
pharmacology
Time Factors
Aging
Sex Factors
Fatty Acids
administration & dosage
Pregnancy
Female
blood
blood
Dose-Response Relationship
Fatty Acids
Rats
blood
Insulin
blood
blood
Animals
Fetus
Diet
Sprague-Dawley
Rats
Fatty Acids
Triglycerides
Cholesterol
Omega-3
Newborn
blood
Författare
Marina Korotkova
Göteborgs universitet
Britt Gabrielsson
Göteborgs universitet
Agneta Holmäng
Göteborgs universitet
Britt-Mari Larsson
Göteborgs universitet
Lars Åke Hanson
Göteborgs universitet
Birgitta Strandvik
Göteborgs universitet
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
0363-6119 (ISSN) 1522-1490 (eISSN)
Vol. 288 3 R575-9Ämneskategorier
MEDICIN OCH HÄLSOVETENSKAP
DOI
10.1152/ajpregu.00342.2004
PubMed
15699360