Association between Gm allotypes and asthma severity from childhood to young middle age.
Artikel i vetenskaplig tidskrift, 2008

Immunoglobulin constant heavy G chain (IGHG) gene polymorphisms are associated with atopy and can be determined by the serum Gm allotypes. We studied whether certain polymorphisms are related to asthma severity and to the extent or intensity of allergic sensitization in asthmatic subjects followed from childhood to young middle age. Fifty-five subjects (28 males) with childhood asthma were all followed-up prospectively on six occasions from a mean age of 9 to 35 years in a study including asthma severity scoring, spirometry, skin prick, and specific serum IgE antibody testing. At the last visit, extended lung function tests and a cold air challenge were performed, and IGHG gene polymorphisms were identified by the alternative serum IgG subclass allotypes, employing ELISA and double immunodiffusion. The 19 subjects with the homozygous IGHG*bf/*bf genotype (originating from the IGHG3*b and the IGHG1*f alleles, which are in strong linkage disequilibrium), showed significantly higher asthma scores, lower airway function, and greater bronchodilator responses from childhood to adulthood, and in middle age greater airway hyperresponsiveness, compared to the subjects with the IGHG*bf/*ga or IGHG*ga/*ga genotypes. Among the subjects sensitized to animal danders, those with the IGHG*bf/*bf genotype showed the highest specific IgE levels. In conclusion, IGHG gene polymorphisms were associated with the severity and outcome of childhood asthma, and with the intensity of allergic sensitization.

Forced Expiratory Volume

Immunoglobulin Heavy Chains

immunology

Humans

genetics

Male

Vital Capacity

immunology

analysis

Epidemiologic Methods

Immunoglobulin E

Enzyme-Linked Immunosorbent Assay

Adolescent

Immunoglobulin Gm Allotypes

immunology

Child

genetics

methods

Genetic

genetics

immunology

Skin Tests

Asthma

physiopathology

Allergens

genetics

Adult

Immunoglobulin G

analysis

Female

Polymorphism

Författare

Per M. Gustafsson

Göteborgs universitet

Vivi-Anne Oxelius

Skånes universitetssjukhus

Staffan Nilsson

Chalmers University of Technology

Sahlgrenska universitetssjukhuset

Bengt Kjellman

Central Hospital Skovde

Respiratory Medicine

0954-6111 (ISSN)

Vol. 102 266-72

Ämneskategorier

Övrig annan samhällsvetenskap

Mikrobiologi inom det medicinska området

DOI

10.1016/j.rmed.2007.09.003

PubMed

17933503