Searching for genes influencing a complex disease: the case of coeliac disease.
Artikel i vetenskaplig tidskrift, 2008

Recently, a few genes have been reported to be causative in inflammatory diseases. Still, we are waiting for the vast majority to be discovered. New tools for genotyping and statistical analysis have been developed and emphasis has been put on study design. Coeliac disease (CD) is a disorder, where prolamins in dietary wheat gluten and related proteins from rye or barley are not tolerated. It is one of the most common chronic diseases in humans exceeding a population prevalence of 1%. In this article, we will summarise what is currently known about the genetics influencing CD with the emphasis on the non-HLA genetic component. We will discuss some difficulties when searching for susceptibility genes in disorders with complex inheritance patterns.

Evolution

Population

genetics

Humans

epidemiology

Genetic Predisposition to Disease

Celiac Disease

Phenotype

Linkage (Genetics)

Genetics

Författare

Åsa Torinsson Naluai

Göteborgs universitet

Henry Ascher

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Jan Wahlström

Göteborgs universitet

European Journal of Human Genetics

1018-4813 (ISSN)

Vol. 16 542-53

Ämneskategorier

Dermatologi och venereologi

DOI

10.1038/sj.ejhg.5201918

PubMed

17726483