Toward Design-based Engineering of Industrial Microbes
Artikel i vetenskaplig tidskrift, 2010

Engineering industrial microbes has been hampered by incomplete knowledge of cell biology. Thus an iterative engineering cycle of modeling, implementation, and analysis has been used to increase knowledge of the underlying biology while achieving engineering goals. Recent advances in Systems Biology technologies have drastically improved the amount of information that can be collected in each iteration. As well, Synthetic Biology tools are melding modeling and molecular implementation. These advances promise to move microbial engineering from the iterative approach to a design-oriented paradigm, similar to electrical circuits and architectural design. Genome-scale metabolic models, new tools for controlling expression, and integrated -omics analysis are described as key contributors in moving the field toward Design-based Engineering. © 2010 Elsevier Ltd. All rights reserved.

Författare

Keith Tyo

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Kanokarn Kocharin

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Jens B Nielsen

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Current Opinion in Microbiology

1369-5274 (ISSN)

Vol. 13 3 255-262

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Bioinformatik och systembiologi

Annan industriell bioteknik

DOI

10.1016/j.mib.2010.02.001