Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies
Artikel i vetenskaplig tidskrift, 2010

A series of 2-benzyl-3-(2-arylidenehydrazinyl)quinoxalines 3, 4-benzyl-1-aryl-[1,2,4]triazolo[4,3-a]quinoxalines 4 and phenyl(1-aryl-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl)methanones 5 analogues were synthesized and investigated for their monoamine oxidase (MAO) inhibitory property. The inhibition profile was found to be competitive for compounds 3k, 3m, 5f and 5n with MAO-A selectivity. Observation of the docked positions of these compounds revealed interactions with many residues previously reported to have an effect on the inhibition of the enzyme. The structural features of the new compounds have been determined from the microanalytical, IR, 1H, 13C NMR spectral studies and X-ray crystalography.

Monoamine oxidase inhibitors

[1

Oxidative cyclization

4]Triazolo[4

Quinoxalines

2

Oxidation

3-a]quinoxalines

Författare

Serine N. Khattab

Alexandria University

Seham Y. Hassan

Alexandria University

Adnan A. Bekhit

Alexandria University

Abdel Moneim El Massry

Alexandria University

Vratislav Langer

Chalmers, Kemi- och bioteknik, Oorganisk miljökemi

Adel Amer

Alexandria University

European Journal of Medicinal Chemistry

0223-5234 (ISSN)

Vol. 45 4479-4489

Ämneskategorier

Läkemedelskemi

Organisk kemi

DOI

10.1016/j.ejmech.2010.07.008