A regio- and stereo-controlled approach to triazoloquinoxalinyl C-nucleosides
Artikel i vetenskaplig tidskrift, 2010

The synthesis of a new series of acyclic triazoloquinoxalinyl C-nucleosides and their transformation to their cyclic analogs are described following protection, activation, and deprotection with subsequent intramolecular nucleophilic substitution protocol. The antibacterial potency of the new compounds was determined using an inhibition zone diameter test. The results show that 3a and 2b exhibit good activity against Escherichia coli and Candida albicans. On the other hand, the cyclic mesylated C-nucleoside 13 showed activity against the Gram-positive bacteria (Staphylococcus aureus) and antifungal activity against C. albicans.

Acyclic triazoloquinoxalinyl C-nucleosides

Antimicrobial activity

Tautomerism

Cyclic triazoloquinoxalinyl C-nucleosides

Författare

Adel Amer

Alexandria University

Mohammes Salah Ayoup

Alexandria University

Serine N. Khattab

Alexandria University

Seham Y. Hassan

Alexandria University

Vratislav Langer

Chalmers, Kemi- och bioteknik, Oorganisk miljökemi

Samir Senior

Alexandria University

Abdel Moneim El Massry

Alexandria University

Carbohydrate Research

0008-6215 (ISSN)

Vol. 345 2474-2484

Ämneskategorier

Läkemedelskemi

Organisk kemi

DOI

10.1016/j.carres.2010.08.010