Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism
Artikel i vetenskaplig tidskrift, 2010

The yeast Saccharomyces cerevisiae is a widely used model organism for studying cell biology, metabolism, cell cycle and signal transduction. Many regulatory pathways are conserved between this yeast and humans, and it is therefore possible to study pathways that are involved in disease development in a model organism that is easy to manipulate and that allows for detailed molecular studies. Here, we briefly review pathways involved in lipid metabolism and its regulation, the regulatory network of general metabolic regulator Snf1 (and its human homologue AMPK) and the proteostasis network with its link to stress and cell death. All the mentioned pathways can be used as model systems for the study of homologous pathways in human cells and a failure in these pathways is directly linked to several human diseases such as the metabolic syndrome and neurodegeneration. We demonstrate how different yeast pathways are conserved in humans, and we discuss the possibilities of using the systems biology approach to study and compare the pathways of relevance with the objective to generate hypotheses and gain new insights.

saccharomyces-cerevisiae

snf1 kinase

rat-liver

yeast systems biology

oxidized proteins

global analysis

transcription factors

energy metabolism

carboxylase

endoplasmic-reticulum stress

upstream kinase

activity

proteostasis

programmed cell-death

Författare

Dina Petranovic Nielsen

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Keith Tyo

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Goutham Vemuri

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Jens B Nielsen

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

FEMS Yeast Research

1567-1356 (ISSN) 1567-1364 (eISSN)

Vol. 10 8 1046-1059

Ämneskategorier

Industriell bioteknik

Mikrobiologi

Fundament

Grundläggande vetenskaper

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1111/j.1567-1364.2010.00689.x