Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men.
Artikel i vetenskaplig tidskrift, 2011

Before the menopause, women are relatively protected against CVD compared with men. The reasons for this sex difference are not completely understood, but hepatic fatty acid metabolism may play a role. The present study aimed to investigate the utilisation of plasma NEFA by the liver and to determine whether they are partitioned differently into ketone bodies and VLDL-TAG in healthy, lean young men and women. Volunteers were studied during a prolonged overnight fast (12-19 h) using an intravenous infusion of [U-¹³C]palmitate. After 12 h fasting, the women had a more advantageous metabolic profile with lower plasma glucose (P < 0·05) and TAG (P < 0·05) but higher plasma NEFA (P < 0·05) concentrations. Plasma 3-hydroxybutyrate (3-OHB) concentrations rose more in women than in men, and the transfer of ¹³C from [U-¹³C]palmitate to plasma [¹³C]3-OHB reached a plateau 6-7 h after the start of the infusion in women but was still increasing at 6 h in men. This implies a slower 3-OHB production rate and/or dilution by other precursor pools in men. In women, the high isotopic enrichment of plasma 3-OHB suggested that systemic plasma fatty acids were the major source of 3-OHB production. However, in men, this was not observed during the course of the study (P < 0·01). There were no sex differences for the incorporation of ¹³C into VLDL1- or VLDL2-TAG. The ability of young women to partition fatty acids towards ketone body production rather than VLDL-TAG may contribute to their more advantageous metabolic profile compared with young men.

Sex Factors

Palmitic Acid

metabolism

metabolism

metabolism

Nonesterified

3-Hydroxybutyric Acid

physiology

metabolism

Adult

Postprandial Period

blood

VLDL

Fasting

Young Adult

Carbon Isotopes

Dietary Fats

Female

blood

Triglycerides

Lipoproteins

Liver

metabolism

blood

Male

blood

blood

Premenopause

Humans

Fatty Acids

Blood Glucose

physiology

Författare

Kyriakoula Marinou

Martin Adiels

Chalmers, Matematiska vetenskaper

Göteborgs universitet

Leanne Hodson

Keith N Frayn

Fredrik Karpe

Barbara A Fielding

British Journal of Nutrition

0007-1145 (ISSN) 1475-2662 (eISSN)

Vol. 105 857-65

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1017/S0007114510004472

PubMed

21251339