Exploring the role of phosphorus substituents on the enantioselectivity of Ru-catalysed ketone hydrogenation using tridentate phosphine-diamine ligands
Artikel i vetenskaplig tidskrift, 2011

Methods to produce a range of new phosphine-diamine ligands from phosphino-aldehydes have been developed and a hypothesis that larger P-substituents would increase the enantioselectivity towards the (S) isomer in Ru-catalysed ketone hydrogenation of acetophenone has been examined; the successful validation of this hypothesis is further evidence that the mechanism of these catalysts involves a secondary amine assisted reduction.

hybrid ligands

asymmetric hydrogenation

aromatic ketones

alkylation

imines

proline

ruthenium hydride complexes

aminophosphine ligands

rhodium

design

Författare

S. D. Phillips

University of St Andrews

Kristian Andersson

Chalmers, Kemi- och bioteknik, Organisk kemi

Nina Kann

Chalmers, Kemi- och bioteknik, Organisk kemi

M. T. Kuntz

Washington and Lee University

M. B. France

Washington and Lee University

P. Wawrzyniak

University of St Andrews

M. L. Clarke

University of St Andrews

Catalysis Science and Technology

2044-4753 (ISSN) 2044-4761 (eISSN)

Vol. 1 8 1336-1339

Ämneskategorier

Kemi

DOI

10.1039/c1cy00253h