High serum total cholesterol is a long-term cause of osteoporotic fracture.
Artikel i vetenskaplig tidskrift, 2011

Risk factors for osteoporotic fractures were evaluated in 1,396 men and women for a period of 20 years. Serum total cholesterol was found to be an independent osteoporotic fracture risk factor whose predictive power improves with time. The purpose of this study was to evaluate long-term risk factors for osteoporotic fracture. A population random sample of men and women aged 25-64 years (the Gothenburg WHO MONICA project, N = 1,396, 53% women) was studied prospectively. The 1985 baseline examination recorded physical activity at work and during leisure time, psychological stress, smoking habits, coffee consumption, BMI, waist/hip ratio, blood pressure, total, HDL and LDL cholesterol, triglycerides, and fibrinogen. Osteoporotic fractures over a period of 20 years were retrieved from the Gothenburg hospital registers. Poisson regression was used to analyze the predictive power for osteoporotic fracture of each risk factor. A total number of 258 osteoporotic fractures occurred in 143 participants (10.2%). As expected, we found that previous fracture, smoking, coffee consumption, and lower BMI each increase the risk for osteoporotic fracture independently of age and sex. More unexpectedly, we found that the gradient of risk of serum total cholesterol to predict osteoporotic fracture significantly increases over time (p = 0.0377). Serum total cholesterol is an independent osteoporotic fracture risk factor whose predictive power improves with time. High serum total cholesterol is a long-term cause of osteoporotic fracture.

epidemiology

epidemiology

etiology

adverse effects

blood

Osteoporotic Fractures

Male

Humans

Anthropometry

Smoking

Cholesterol

blood

Epidemiologic Methods

Recurrence

adverse effects

Coffee

Motor Activity

Female

methods

Life Style

epidemiology

Middle Aged

Sweden

Adult

Författare

Penelope Trimpou

Göteborgs universitet

Anders Odén

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Tomas Simonsson

Göteborgs universitet

Lars Wilhelmsen

Göteborgs universitet

Kerstin Landin-Wilhelmsen

Göteborgs universitet

Osteoporosis International

0937-941X (ISSN) 1433-2965 (eISSN)

Vol. 22 5 1615-20

Ämneskategorier

Dermatologi och venereologi

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1007/s00198-010-1367-2

PubMed

20821192