Kinetic Studies to Investigate Lipoprotein Metabolism.
Reviewartikel, 2011

To develop novel strategies for prevention and treatment of dyslipidaemia, it is essential to understand the pathophysiology of dyslipoproteinaemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labelled with stable isotopes and mathematical modelling provides a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering understanding of the pathogenesis of dyslipoproteinaemia.

Kinetics

apolipoprotein

VLDL

mathematical modelling

Författare

Jan Borén

Göteborgs universitet

Marja-Riitta Taskinen

Martin Adiels

Göteborgs universitet

Chalmers, Matematiska vetenskaper

Journal of Internal Medicine

0954-6820 (ISSN) 1365-2796 (eISSN)

Vol. 271 2 166-173

Ämneskategorier

Beräkningsmatematik

Cell- och molekylärbiologi

DOI

10.1111/j.1365-2796.2011.02497.x

PubMed

22142374