Applications of the Nicholas Reaction in the Synthesis of Natural Products
Reviewartikel, 2012

The Nicholas reaction involves the treatment of a cobalt carbonyl-stabilized propargylic cation with a variety of nucleophiles to form a new carbon-carbon or carbon-heteroatom bond. Several features of this reaction make it especially well suited for applications in natural product synthesis, in particular when cyclic and polycyclic target molecules are involved. This review summarizes the results in this area from the last ten years, including approaches towards terpenes, alkaloids and marine natural products.

natural product

cobalt alkyne complex

enantioselective syntheses

Nicholas reaction

formal synthesis

jklm-ring fragment

organic-synthesis

propargylic substitution

synthesis

ciguatoxin 1b

8-membered cyclic ethers

Alkaloid

synthesis

marine polyether

stereoselective-synthesis

terpene

convergent

acetylene cobalt complex

Författare

Nina Kann

Chalmers, Kemi- och bioteknik, Organisk kemi

Current Organic Chemistry

1385-2728 (ISSN)

Vol. 16 3 322-334

Ämneskategorier

Organisk kemi

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Senast uppdaterat

2021-07-22