Evidence for membrane flow through pores in stacked phospholipid membranes
Artikel i vetenskaplig tidskrift, 2012

We present evidence for an inter-bilayer transport mode of lipid molecules in solid-supported double bilayer membranes via membrane defects. The observation of avalanche rupturing in isolated membrane areas of flat giant unilamellar vesicles, i.e., double bilayers, in the distal (with respect to the solid support) bilayer revealed migration of the membrane material between the stacked bilayers, which we can explain by the presence of defects. The presence of the interconnections was indirectly observed by monitoring the area development of the isolated membrane patches during rupturing. These new findings can help to better describe the dynamic processes in biological structures, featuring stacks of phospholipid bilayers, such as mitochondrial shape dynamics.

adsorption

lipid-bilayers

fusion

vesicles

protein

liposomes

lamellar phase

size

line tension

biological-membranes

Författare

Irep Gözen

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Paul Gunnar Dommersnes

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Owe Orwar

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Aldo Jesorka

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Soft Matter

1744-683X (ISSN) 1744-6848 (eISSN)

Vol. 8 23 6220-6225

Ämneskategorier

Kemi

DOI

10.1039/c2sm25629k