Solid-Phase Synthesis of 5 '-O- N-(Acyl)sulfamoyl adenosine Derivatives
Artikel i vetenskaplig tidskrift, 2012
The solid-phase synthesis of 5'-O-[N-(acyl)sulfamoyl]adenosine derivatives is described. The use of a Rink amide polystyrene solid support together with an appropriately protected ribo-purine starting material allowed for the development of a highly reliable and practical route for the solid-phase synthesis of 5'-O-[N-(acyl)sulfamoyl]adenosines. The developed procedure enables the efficient parallel synthesis of the target compounds in high yields. These compounds are non-hydrolysable isosteres of acyl-adenylates, which play an important role in a range of different metabolic pathways such as ribosomal and non-ribosomal peptide synthesis, fatty acid oxidation or enzyme regulation; some adenylate-forming enzymes are potential drug targets.
siderophore
adenylate
transfer-rna synthetase
Synthetic methods
mycobacterium-tuberculosis
Nucleosides
pantothenate synthetase
Solid-phase synthesis
Enzymes
Medicinal chemistry
acid
antibiotics
inhibitors
biosynthesis
analogs
Författare
Itedale Namro Redwan
Göteborgs universitet
Hanna Jacobson Ingemyr
Göteborgs universitet
Thomas Ljungdahl
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Christopher Lawson
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Morten Grötli
Göteborgs universitet
European Journal of Organic Chemistry
1434-193X (ISSN) 10990690 (eISSN)
Vol. 2012 19 3665-3669Ämneskategorier
Farmaceutisk synteskemi
DOI
10.1002/ejoc.201200329