High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden.
Artikel i vetenskaplig tidskrift, 2012

Adipocytes and osteoblasts share a common progenitor, and there is, therefore, potential for both autocrine and endocrine effects of adiponectin on skeletal metabolism. The aim of the present study was to determine whether high serum adiponectin was associated with an increased risk of fracture in elderly men. We studied the relationship between serum adiponectin and the risk of fracture in 999 elderly men drawn from the general population and recruited to the Osteoporotic Fractures in Men (MrOS) study in Gothenburg, Sweden. Baseline data included general health questionnaires, lifestyle questionnaires, body mass index (BMI), bone mineral density (BMD), serum adiponectin, osteocalcin, and leptin. Men were followed for up to 7.4 years (average, 5.2 years). Poisson regression was used to investigate the relationship between serum adiponectin, other risk variables and the time-to-event hazard function of fracture. Median levels of serum adiponectin at baseline were 10.4 µg/mL (interquartile range, 7.7-14.3). During follow-up, 150 men sustained one or more fractures. The risk of fracture increased in parallel with increasing serum adiponectin (hazard ratio [HR]/SD, 1.46; 95% confidence interval [CI], 1.23-1.72) and persisted after multivariate-adjusted analysis (HR/SD, 1.30; 95% CI, 1.09-1.55). Serum adiponectin shows graded stepwise association with a significant excess risk of fracture in elderly men that was independent of several other risk factors for fracture. Its measurement holds promise as a risk factor for fracture in men.

SPLINE POISSON REGRESSION MODEL

INCIDENT FRACTURES

ELDERLY MEN

ADIPONECTIN

Författare

Helena Johansson

Göteborgs universitet

Anders Odén

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Ulf H Lerner

Göteborgs universitet

Hans Jutberger

Göteborgs universitet

Mattias Lorentzon

Göteborgs universitet

Elizabeth Barrett-Connor

Magnus K Karlsson

Östen Ljunggren

Ulf Smith

Göteborgs universitet

Eugene McCloskey

John A Kanis

Claes Ohlsson

Göteborgs universitet

Dan Mellström

Göteborgs universitet

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

1523-4681 (ISSN)

Vol. 27 6 1390-6

Ämneskategorier

Klinisk medicin

Ortopedi

DOI

10.1002/jbmr.1591

PubMed

22407876

Mer information

Skapat

2017-10-07