Combining scanning haptic microscopy and fibre optic Raman spectroscopy for tissue characterization
Artikel i vetenskaplig tidskrift, 2012

The tactile resonance method (TRM) and Raman spectroscopy (RS) are promising for tissue characterization in vivo. Our goal is to combine these techniques into one instrument, to use TRM for swift scanning, and RS for increasing the diagnostic power. The aim of this study was to determine the classification accuracy, using support vector machines, for measurements on porcine tissue and also produce preliminary data on human prostate tissue. This was done by developing a new experimental set-up combining micro-scale TRM—scanning haptic microscopy (SHM)—for assessing stiffness on a micro-scale, with fibre optic RS measurements for assessing biochemical content. We compared the accuracy using SHM alone versus SHM combined with RS, for different degrees of tissue homogeneity. The cross-validation classification accuracy for healthy porcine tissue types using SHM alone was 65–81%, and when RS was added it increased to 81–87%. The accuracy for healthy and cancerous human tissue was 67–70% when only SHM was used, and increased to 72–77% for the combined measurements. This shows that the potential for swift and accurate classification of healthy and cancerous prostate tissue is high. This is promising for developing a tool for probing the surgical margins during prostate cancer surgery.

Raman spectroscopy

Tactile resonance method

Tissue characterization

Prostate cancer

Support vector machines


Stefan Candefjord

Signaler och system, Signalbehandling och medicinsk teknik, Biomedicinsk elektromagnetik

Yoshinobu Murayama

Nihon University

Lulea tekniska Universitet

M. Nyberg

Lulea tekniska Universitet

Josef Hallberg

Lulea tekniska Universitet

Kerstin Ramser

Lulea tekniska Universitet

Börje Ljungberg

Umea universitet

Anders Bergh

Umea universitet

O. A. Lindahl

Lulea tekniska Universitet

Umea universitet

Journal of Medical Engineering and Technology

0309-1902 (ISSN)

Vol. 36 319-327


Medicinsk laboratorie- och mätteknik


Innovation och entreprenörskap


Livsvetenskaper och teknik