PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
Artikel i vetenskaplig tidskrift, 2012

Background: Obesity is a risk factor for cancer, including hepatocellular carcinoma. Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) genetic variant has been associated with hepatocellular carcinoma (HCC) in individuals with chronic alcohol abuse or hepatic viral infection. In the present study we examined the association between the PNPLA3I148M genetic variant and hepatocellular carcinoma in obese individuals from the Swedish Obese Subjects cohort (n=4047). Methods: We performed a matched, prospective, controlled, interventional trial, investigating the effect of bariatric surgery (surgery group) compared to conventional treatment (control group) for obesity. Results: A total of 9 events were observed in the 15-year median follow up (5 in the control group and 4 in the surgery group). A significantly higher incidence of hepatocellular carcinoma in PNPLA3 148M allele carriers was found in obese individuals in the control group (log-rank P-value=0.001), but not in the surgery group (log-rank P-value=0.783). Consistently, an increased risk (for each PNPLA3 148M allele, hazard ratio: 5.9; 95% confidence interval 1.5-23.8; P-value=0.013) of developing hepatocellular carcinoma was observed only in the control group. Conclusion: The current study is the first prospective report showing the association of the PNPLA3I148M genetic variant and hepatocellular carcinoma in severely obese individuals.

polymorphism

Obesity

histological severity

susceptibility

Patatin-like phospholipase domain-containing 3

fatty liver-disease

bariatric surgery

Swedish obese subjects study

indexes

mortality

cirrhosis

adiponutrin

Liver cancer

risk

Författare

Maria A Burza

Göteborgs universitet

Carlo Pirazzi

Göteborgs universitet

Cristina Maglio

Göteborgs universitet

Kajsa Sjöholm

Göteborgs universitet

Rosellina Margherita Mancina

Göteborgs universitet

Per-Arne Svensson

Göteborgs universitet

Peter Jacobson

Göteborgs universitet

Martin Adiels

Göteborgs universitet

M. G. Baroni

Jan Borén

Göteborgs universitet

S. G. Corradini

T. Montalcini

Lars Sjöström

Göteborgs universitet

Lena M S Carlsson

Göteborgs universitet

Stefano Romeo

Göteborgs universitet

Digestive and Liver Disease

1590-8658 (ISSN)

Vol. 44 12 1037-1041

Ämneskategorier

Klinisk medicin

DOI

10.1016/j.dld.2012.05.006