Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement therapy.
Artikel i vetenskaplig tidskrift, 2012

bjective: GH deficiency (GHD) in adults is associated with an altered serum lipid profile that responds to GH replacement therapy (GHRT). This study evaluated the influence of polymorphisms in genes related to lipid metabolism on serum lipid profile before and after 1 year of GHRT in adults. Design and methods: In 318 GHD patients, total cholesterol (TC) serum concentrations, LDL-C, HDL-C, and triglycerides (TG) were assessed. Using a candidate gene approach, 20 single nucleotide polymorphisms (SNPs) were genotyped. GH dose was individually titrated to obtain normal serum IGF1 concentrations. Results: At baseline, the minor alleles of cholesteryl ester transfer protein (CETP) gene SNPs rs708272 and rs1800775 were associated with higher serum TC and apolipoprotein E (APOE) gene SNP rs7412 with lower TC concentrations; CETP SNPs rs708272, rs1800775, and rs3764261 and apolipoprotein B (APOB) gene SNP rs693 with higher serum HDL-C; APOE SNP rs7412, peroxisome proliferator-activated receptor gamma (PPARG) gene SNP rs10865710 with lower LDL-C, and CETP SNP rs1800775 with higher LDL-C; and APOE/C1/C4/C2 cluster SNP rs35136575 with lower serum TG. After treatment, APOB SNP rs676210 GG genotype was associated with larger reductions in TC and LDL-C and PPARG SNP rs10865710 CC genotype with greater TC reduction. All associations remained significant when adjusted for age, sex, and BMI. Conclusions: In GHD adults, multiple SNPs in genes related to lipid metabolism contributed to individual differences in baseline serum lipid profile. The GH treatment response in TC and LDL-C was influenced by polymorphisms in the APOB and PPARG genes.

Dwarfism

Aged

Time Factors

blood

deficiency

Adolescent

Humans

therapeutic use

Lipid Metabolism

Human Growth Hormone

Cohort Studies

drug therapy

Genetic Variation

blood

Young Adult

Longitudinal Studies

Female

genetics

Lipids

Genotype

Pituitary

Adult

physiology

Prospective Studies

Middle Aged

genetics

Male

Författare

Edna J L Barbosa

Göteborgs universitet

Camilla A M Glad

Göteborgs universitet

Anna G Nilsson

Göteborgs universitet

Helena Filipsson Nyström

Göteborgs universitet

Galina Götherström

Göteborgs universitet

Per-Arne Svensson

Göteborgs universitet

Isabela Vinotti

Universidade Federal do Parana

Bengt-Åke Bengtsson

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Cesar Luiz Boguszewski

Universidade Federal do Parana

Gudmundur Johannsson

Göteborgs universitet

European Journal of Endocrinology

08044643 (ISSN) 1479683X (eISSN)

Vol. 167 353-62

Ämneskategorier

Klinisk medicin

DOI

10.1530/EJE-12-0263

PubMed

22715478