Fracture risk assessment
Artikel i vetenskaplig tidskrift, 2012

Having traditionally relied on measurements of bone mineral density, it is now established that the consideration of other risk variables improves the categorisation of fracture risk. Whereas several models are available, the FRAX models are the most extensively used. The approach uses easily obtained clinical risk factors to estimate 10 year fracture probability, with or without femoral neck bone mineral density (BMD), to enhance fracture risk prediction. It has been constructed and validated using primary data from population based cohorts around the world, including centres from North America, Europe, Asia and Australia. The FRAX® tool should not be considered as a gold standard, but rather as a platform technology on which to build as new validated risk indicators become available. Notwithstanding, the present models provide an aid to enhance patient assessment by the integration of clinical risk factors alone and/or in combination with BMD.

Rheumatoid

Alcohol Drinking

epidemiology

Models

complications

Biological

Risk Factors

adverse effects

Risk Assessment

adverse effects

complications

Disease Susceptibility

Arthritis

Software

Osteoporosis

Bone

etiology

Humans

Fractures

Incidence

Algorithms

Glucocorticoids

Författare

Eugene McCloskey

Helena Johansson

John A Kanis

Clinical biochemistry

1873-2933 (ISSN)

Vol. 45 887-93

Ämneskategorier

Endokrinologi och diabetes

DOI

10.1016/j.clinbiochem.2012.05.001

PubMed

22579965