Functional Mannose-Binding Lectin Haplotype Variants are Associated with Alzheimer's Disease
Artikel i vetenskaplig tidskrift, 2013

Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimer's disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymorphisms, linked to MBL deficiency, in the corresponding MBL2 gene in AD patients and controls. Two MBL2 haplotypes, LXP and LYQ, were significantly associated with AD risk (OR = 1.6, p = 0.01 and OR = 1.5, p = 0.02, respectively). The present study is the first investigating MBL2 genotypes and haplotypes in relation to AD. Our findings support that the MBL2 gene impact the disease risk.

Författare

Annica Sjölander

Göteborgs universitet

L. Minthon

Lunds universitet

L. Nuytinck

Universiteit Gent

E. Vanmechelen

Key4AD

Kaj Blennow

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Journal of Alzheimers Disease

1387-2877 (ISSN)

Vol. 35 1 121-127

Ämneskategorier

Neurovetenskaper

DOI

10.3233/jad-122044

Mer information

Senast uppdaterat

2018-03-06