A possible association between panic disorder and a polymorphism in the preproghrelin gene
Artikel i vetenskaplig tidskrift, 2013

The aim of the study was to investigate whether polymorphisms in the preproghrelin gene are associated with anxiety disorders, such as panic disorder, in humans. Panic disorder is a severe anxiety disorder, characterized by sudden attacks of intense fear or anxiety in combination with somatic symptoms. The preproghrelin gene codes for two gut-derived circulating peptides that have been linked to anxiety-like behaviour in rodents: ghrelin (an orexigenic, pro-obesity hormone) and obestatin. In the present study, we genotyped three missense mutations in the preproghrelin gene in 215 patients suffering from panic disorder and in 451 controls. The A allele of the rs4684677 polymorphism was significantly associated with panic disorder, while there were no significant associations with the two other polymorphisms studied. We conclude that the rs4684677 (Gln90Leu) polymorphism in the preproghrelin gene may be associated with increased risk of panic disorder. It will be important to confirm these findings in additional panic disorder patient groups.

Gln90Leu

Ghrelin

Obestatin

Anxiety

rs4684677

SNP

Panic disorder

Författare

Caroline Hansson

Göteborgs universitet

Kristina Annerbrink

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Jessica Bah

Göteborgs universitet

Marie Olsson

Göteborgs universitet

Christer Allgulander

Karolinska Institutet

Sven Andersch

Göteborgs universitet

I. Sjodin

Linköpings universitet

Elias Eriksson

Göteborgs universitet

Suzanne L. Dickson

Göteborgs universitet

Psychiatry Research

0165-1781 (ISSN)

Vol. 206 22-25

Ämneskategorier

Psykiatri

DOI

10.1016/j.psychres.2012.09.051

PubMed

23084284