Empirical to mechanistic modelling in high shear granulation
Artikel i vetenskaplig tidskrift, 2005

This paper gives an overview of the different models available for granulation in high shear mixers with a focus on applicability in the pharmaceutical industry. Three examples of applications are given. The examples indicate the potential of mechanistically based models for scale-up and the importance of understanding the dynamics of the granulation process. The first two examples show how the impeller torque can be modelled and predicted in the dry and wet mixing phases of the high shear granulation process, using a solid mechanics and a hierarchical multivariate model, respectively. In the third application the particle size distribution is modelled using population balances and it is shown how different operating conditions can be included in the coalescence kernel to describe the granule growth.


Multivariate modelling

Solid mechanics



Population balance


Ingela Niklasson Björn

Anders Jansson

Chalmers, Kemi- och bioteknik, Kemisk apparatteknik

Magnus Karlsson

Staffan Folestad

Anders Rasmuson

Chalmers, Kemi- och bioteknik, Kemisk apparatteknik

Chemical Engineering Science

Vol. 60 3795-3803


Annan kemiteknik

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