Protrusive growth and periodic contractile motion in surface-adhered vesicles induced by Ca2+-gradients
Artikel i vetenskaplig tidskrift, 2010

Local signaling, cell polarization, and protrusive growth are key steps in directed migration of biological cells guided by chemical gradients. Here we present a minimal system which captures several key features of cellular migration from signaling-to-motion. The model system consists of flat, negatively charged phospholipid vesicles, a negatively charged surface, and a local, and controllable point-source supply of calcium ions. In the presence of a Ca2+ gradient, the surface-adhered vesicles form protrusions in the direction of the gradient. We also observe membrane shape oscillations between expanded (flattened), and spherical states as a function of the Ca2+-concentration. The observed phenomena can be of importance in explaining motile action in prebiotic, primitive, and biomimetic systems, as well as in development of novel soft-matter nano-and microscale mechanical devices.

bilayer-membranes

lipid nanotubes

phosphatidylserine

liposomes

cells

calcium

tension

curvature

chemotaxis

networks

Författare

Tatsiana Lobovkina

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Irep Gözen

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Yavuz Erkan

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Jessica Olofsson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

S. G. Weber

Owe Orwar

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Soft Matter

1744-683X (ISSN) 1744-6848 (eISSN)

Vol. 6 2 268-272

Ämneskategorier

Kemi

DOI

10.1039/b916805m