Block bootstrap methods for the estimation of the intensity of a spatial point process with confidence bounds
Artikel i vetenskaplig tidskrift, 2013

This paper deals with the estimation of the intensity of a planar point process on the basis of a single point pattern, observed in a rectangular window. If the model assumptions of stationarity and isotropy hold, the method of block bootstrapping can be used to estimate the intensity of the process with confidence bounds. The results of two variants of block bootstrapping are compared with a parametric approximation based on the assumption of a Gaussian distribution of the numbers of points in deterministic subwindows of the original pattern. The studies were performed on patterns obtained by simulation of well-known point process models (Poisson process, two Matern cluster processes, Matern hardcore process, Strauss hardcore process). They were also performed on real histopathological data (point patterns of capillary profiles of 12 cases of prostatic cancer). The methods are presented as worked examples on two cases, where we illustrate their use as a check on stationarity (homogeneity) of a point process with respect to different fields of vision. The paper concludes with various methodological discussions and suggests possible extensions of the block bootstrap approach to other fields of spatial statistics.

sections

capillaries

computer-intensive methods

Bootstrap

sample reuse methods

patterns

dependent data

variance

intensity

statistical-analysis

pathology

point process

dependent data

Författare

T. Mattfeldt

Universitat Ulm

Henrike Häbel

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

SuMo Biomaterials

F. Fleischer

Boehringer Ingelheim Pharma GmbH & Co. KG

Journal of Microscopy

0022-2720 (ISSN) 1365-2818 (eISSN)

Vol. 251 84-98

Ämneskategorier

Annan teknik

Cell- och molekylärbiologi

Sannolikhetsteori och statistik

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1111/jmi.12048