Protein-serine/threonine/tyrosine kinases in bacterial signaling and regulation
Artikel i vetenskaplig tidskrift, 2013

In this review, we address some recent developments in the field of bacterial protein phosphorylation, focusing specifically on serine/threonine and tyrosine kinases. We present an overview of recent studies outlining the scope of physiological processes that are regulated by phosphorylation, ranging from cell cycle, growth, cell morphology, to metabolism, developmental phenomena, and virulence. Specific emphasis is placed on Mycobacterium tuberculosis as a showcase organism for serine/threonine kinases, and Bacillus subtilis to illustrate the importance of protein phosphorylation in developmental processes. We argue that bacterial serine/threonine and tyrosine kinases have a distinctive feature of phosphorylating multiple substrates and might thus represent integration nodes in the signaling network. Some open questions regarding the evolutionary benefits of relaxed substrate selectivity of these kinases are treated, as well as the notion of nonfunctional background' phosphorylation of cellular proteins. We also argue that phosphorylation events for which an immediate regulatory effect is not clearly established should not be dismissed as unimportant, as they may have a role in cross-talk with other post-translational modifications. Finally, recently developed methods for studying protein phosphorylation networks in bacteria are briefly discussed.

regulatory network

development

pathogenic bacteria

phosphoproteomics

protein phosphorylation

Författare

C. Cousin

Microbiologie de l'Alimentation au Service de la Sante Humaine

A. Derouiche

Microbiologie de l'Alimentation au Service de la Sante Humaine

L. Shi

Microbiologie de l'Alimentation au Service de la Sante Humaine

Y. Pagot

Microbiologie de l'Alimentation au Service de la Sante Humaine

S. Poncet

Microbiologie de l'Alimentation au Service de la Sante Humaine

Ivan Mijakovic

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

FEMS Microbiology Letters

0378-1097 (ISSN)

Vol. 346 11-19

Ämneskategorier

Mikrobiologi

DOI

10.1111/1574-6968.12189