Understanding the interactions between bacteria in the human gut through metabolic modeling
Artikel i vetenskaplig tidskrift, 2013

The human gut microbiome plays an influential role in maintaining human health, and it is a potential target for prevention and treatment of disease. Genome-scale metabolic models (GEMs) can provide an increased understanding of the mechanisms behind the effects of diet, the genotype-phenotype relationship and microbial robustness. Here we reconstructed GEMs for three key species, (Bacteroides thetaiotamicron, Eubacterium rectale and Methanobrevibacter smithii) as relevant representatives of three main phyla in the human gut (Bacteroidetes, Firmicutes and Euryarchaeota). We simulated the interactions between these three bacteria in different combinations of gut ecosystems and compared the predictions with the experimental results obtained from colonization of germ free mice. Furthermore, we used our GEMs for analyzing the contribution of each species to the overall metabolism of the gut microbiota based on transcriptome data and demonstrated that these models can be used as a scaffold for understanding bacterial interactions in the gut.

MUTUALISM

HEALTH

METHANOBREVIBACTER-SMITHII

NETWORK

LARGE-INTESTINE

HUMAN COLONIC MICROBIOTA

METAGENOME

ABSORPTION

BUTYRATE

DIET

Författare

Saeed Shoaie

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Fredrik Karlsson

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Adil Mardinoglu

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Intawat Nookaew

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Sergio Velasco

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Jens B Nielsen

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Scientific Reports

2045-2322 (ISSN)

Vol. 3 2532

Infrastruktur

C3SE (Chalmers Centre for Computational Science and Engineering)

Ämneskategorier

Annan naturvetenskap

DOI

10.1038/srep02532