Genetic Variants of Coagulation Factor XI Show Association with Ischemic Stroke Up to 70 Years of Age
Artikel i vetenskaplig tidskrift, 2013

Coagulation factor XI (FXI) has an important role in the propagation and stabilization of a thrombus upon vessel injury. High FXI levels have been implicated in thrombotic diseases including ischemic stroke. The aim of our study was to investigate whether FXI gene (F11) variants are associated with ischemic stroke. The discovery sample, the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), included 844 patients with ischemic stroke and 668 controls, all aged 18-70 years. Replication was performed in the Lund Stroke Register (LSR) and Malmö Diet and Cancer study (MDC), together including 1213 patients and 788 controls up to 70 years of age, and in total 3145 patients and 1793 controls (18-102 years). Seven F11 single-nucleotide polymorphisms (SNPs) were selected using a tagging approach. The SNPs rs3733403, rs925451, and rs1593 showed independent associations with overall ischemic stroke in SAHLSIS, ORs of 0.74 (95% CI 0.59-0.94), 1.24 (95% CI 1.06-1.46), and 0.70 (95% CI 0.55-0.90), respectively. The association for rs925451 was replicated in the LSR and MDC sample in a pre-specified analysis of subjects aged 70 years or younger, OR of 1.16 (95% CI 1.00-1.34), whereas no SNP was replicated when all ages were included. In line with this, one F11 haplotype was associated with overall ischemic stroke in the discovery sample and in the replication sample ≤70 years. We found significant associations between F11 variation and overall ischemic stroke up to 70 years of age. These findings motivate further studies on the role of F11 in ischemic stroke, especially in younger individuals.

Hemorrhage

Genetics of disease

Haplotypes

Thrombin

Genotyping

Ischemic stroke

Blood plasma

Diet

Författare

Ellen Hanson

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Katarina Jood

Göteborgs universitet

Bo Norrving

Skånes universitetssjukhus (SUS)

Lunds universitet

Gunnar Engström

Lunds universitet

Christian Blomstrand

Göteborgs universitet

Arne Lindgren

Skånes universitetssjukhus (SUS)

Lunds universitet

Olle Melander

Lunds universitet

Christina Jern

Göteborgs universitet

PLoS ONE

1932-6203 (ISSN)

Vol. 8 9 artikel nr e75286- e75286

Ämneskategorier

Klinisk medicin

DOI

10.1371/journal.pone.0075286

Mer information

Senast uppdaterat

2018-05-14