Synthesis and photophysical characterization of 1-and 4-(purinyl) triazoles
Artikel i vetenskaplig tidskrift, 2013
Fluorescent adenine mimetics are useful tools for studying DNA, RNA and enzyme functions. Herein we describe the synthesis of eight 1-(purinyl)triazoles and two 4-(purinyl)triazoles utilizing the 1,4-regioselective copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction as the key step. The fluorescence properties of five of the synthesized 1-(purinyl)triazoles are also presented. The five measured compounds displayed low quantum yields. The results, when compared to previously published data, suggest a high influence of the substitution pattern of the triazole on the fluorescence properties.
ADENYLATE ANALOGS
INHIBITORS
METHIONYL-TRANSFER-RNA
Fluorescent purines
MYCOBACTERIUM-TUBERCULOSIS
DESIGN
SYNTHETASE
Purinyltriazole
ACID
ISOLEUCYL ADENYLATES
PANTOTHENATE
TRANSFER-RNA SYNTHETASE
SIDEROPHORE BIOSYNTHESIS
CuAAc
Författare
Itedale Namro Redwan
Göteborgs universitet
David Bliman
Göteborgs universitet
Munefumi Tokugawa
Göteborgs universitet
Christopher Lawson
Göteborgs universitet
Morten Grötli
Göteborgs universitet
Tetrahedron
0040-4020 (ISSN)
Vol. 69 42 8857-8864Ämneskategorier
Biokemi och molekylärbiologi
DOI
10.1016/j.tet.2013.08.023