Synthesis and photophysical characterization of 1-and 4-(purinyl) triazoles
Artikel i vetenskaplig tidskrift, 2013

Fluorescent adenine mimetics are useful tools for studying DNA, RNA and enzyme functions. Herein we describe the synthesis of eight 1-(purinyl)triazoles and two 4-(purinyl)triazoles utilizing the 1,4-regioselective copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction as the key step. The fluorescence properties of five of the synthesized 1-(purinyl)triazoles are also presented. The five measured compounds displayed low quantum yields. The results, when compared to previously published data, suggest a high influence of the substitution pattern of the triazole on the fluorescence properties.

SYNTHETASE

Purinyltriazole

MYCOBACTERIUM-TUBERCULOSIS

Fluorescent purines

PANTOTHENATE

INHIBITORS

TRANSFER-RNA SYNTHETASE

METHIONYL-TRANSFER-RNA

SIDEROPHORE BIOSYNTHESIS

ACID

ADENYLATE ANALOGS

CuAAc

ISOLEUCYL ADENYLATES

DESIGN

Författare

Itedale Namro Redwan

Göteborgs universitet

David Bliman

Göteborgs universitet

Munefumi Tokugawa

Göteborgs universitet

Christopher Lawson

Göteborgs universitet

Morten Grøtli

Göteborgs universitet

Tetrahedron

0040-4020 (ISSN)

Vol. 69 8857-8864

Ämneskategorier

Biokemi och molekylärbiologi

DOI

10.1016/j.tet.2013.08.023