Synthesis and photophysical characterization of 1-and 4-(purinyl) triazoles
Artikel i vetenskaplig tidskrift, 2013

Fluorescent adenine mimetics are useful tools for studying DNA, RNA and enzyme functions. Herein we describe the synthesis of eight 1-(purinyl)triazoles and two 4-(purinyl)triazoles utilizing the 1,4-regioselective copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction as the key step. The fluorescence properties of five of the synthesized 1-(purinyl)triazoles are also presented. The five measured compounds displayed low quantum yields. The results, when compared to previously published data, suggest a high influence of the substitution pattern of the triazole on the fluorescence properties.

ADENYLATE ANALOGS

INHIBITORS

METHIONYL-TRANSFER-RNA

Fluorescent purines

MYCOBACTERIUM-TUBERCULOSIS

DESIGN

SYNTHETASE

Purinyltriazole

ACID

ISOLEUCYL ADENYLATES

PANTOTHENATE

TRANSFER-RNA SYNTHETASE

SIDEROPHORE BIOSYNTHESIS

CuAAc

Författare

Itedale Namro Redwan

Göteborgs universitet

David Bliman

Göteborgs universitet

Munefumi Tokugawa

Göteborgs universitet

Christopher Lawson

Göteborgs universitet

Morten Grötli

Göteborgs universitet

Tetrahedron

0040-4020 (ISSN)

Vol. 69 8857-8864

Ämneskategorier

Biokemi och molekylärbiologi

DOI

10.1016/j.tet.2013.08.023