Accurate T1 mapping for oxygen-enhanced MRI in the mouse lung using a segmented inversion-recovery ultrashort echo-time sequence.
Artikel i vetenskaplig tidskrift, 2014

Purpose: A segmented inversion-recovery module combined with the 2D ultrashort echo time radial technique is proposed that allows accurate pixel level T-1 mapping of mouse lung in vivo. Methods: Numerical simulations were performed to estimate T-1 measurement accuracy and precision versus flip angle and signal-to-noise ratio. Phantom measurements were used for protocol validation, where the segmented inversion-recovery ultrashort echo-time sequence was compared with the reference technique (inversion-recovery rapid acquisition with refocused echoes). The in vivo experiments were carried out on free-breathing C57 mice (n = 10), breathing first air and then oxygen. Results: The simulations demonstrated the high potential of the technique for accurate and precise T-1 assessment. Phantom experiments showed good agreement for T-1 values measured with segmented inversion-recovery ultrashort echo-time and the reference technique. The in vivo experiment demonstrated the utility of the technique in oxygen-enhanced assessment, where small T-1 changes were detected with high precision. Conclusion: Segmented inversion-recovery ultrashort echo-time provides accurate, high resolution T-1 mapping of the lung parenchyma. Magn Reson Med 71:2180-2185, 2014. (c) 2013 Wiley Periodicals, Inc.

T-1 mapping

ultrashort echo-time

lung MRI

segmented inversion recovery

oxygen-enhanced imaging




M Zurek

AstraZeneca Sweden

E Johansson

AstraZeneca Sweden

F Risse

AstraZeneca Sweden

Daniel Alamidi

Göteborgs universitet

Lars E Olsson

Lunds Universitet

Paul Hockings

Signaler och system, Signalbehandling och medicinsk teknik, Signalbehandling

Magnetic Resonance in Medicine

0740-3194 (ISSN) 1522-2594 (eISSN)

Vol. 71 2180-2185


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