SNPs within the GH-signaling pathway are associated with the early IGF1 response to GH replacement therapy in GHD adults.
Artikel i vetenskaplig tidskrift, 2014
GH-deficient (GHD) adults have reduced serum concentrations of IGF1. GH replacement therapy increases serum IGF1 concentrations, but the interindividual variation in treatment response is large and likely influenced by genetic factors. This study was designed to test the hypothesis that single-nucleotide polymorphisms (SNPs) in genes within the GH signaling pathway influence the serum IGF1 response to GH replacement.
Författare
Camilla A M Glad
Göteborgs universitet
Edna J L Barbosa
Göteborgs universitet
Helena Filipsson Nyström
Göteborgs universitet
Lena M S Carlsson
Göteborgs universitet
Staffan Nilsson
Chalmers, Matematiska vetenskaper, Matematisk statistik
Göteborgs universitet
Anna G Nilsson
Göteborgs universitet
Per-Arne Svensson
Göteborgs universitet
Gudmundur Johannsson
Göteborgs universitet
European Journal of Endocrinology
08044643 (ISSN) 1479683X (eISSN)
Vol. 170 1 101-7Ämneskategorier
Annan medicin och hälsovetenskap
DOI
10.1530/EJE-13-0685
PubMed
24114431