SNPs within the GH-signaling pathway are associated with the early IGF1 response to GH replacement therapy in GHD adults.
Artikel i vetenskaplig tidskrift, 2014

GH-deficient (GHD) adults have reduced serum concentrations of IGF1. GH replacement therapy increases serum IGF1 concentrations, but the interindividual variation in treatment response is large and likely influenced by genetic factors. This study was designed to test the hypothesis that single-nucleotide polymorphisms (SNPs) in genes within the GH signaling pathway influence the serum IGF1 response to GH replacement.

Författare

Camilla A M Glad

Göteborgs universitet

Edna J L Barbosa

Göteborgs universitet

Helena Filipsson Nyström

Göteborgs universitet

Lena M S Carlsson

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Anna G Nilsson

Göteborgs universitet

Per-Arne Svensson

Göteborgs universitet

Gudmundur Johannsson

Göteborgs universitet

European Journal of Endocrinology

08044643 (ISSN) 1479683X (eISSN)

Vol. 170 101-7

Ämneskategorier

Annan medicin och hälsovetenskap

DOI

10.1530/EJE-13-0685

PubMed

24114431