Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro
Artikel i vetenskaplig tidskrift, 2014

Background: Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role in the osseointegration of implantable devices. Methods: In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm) to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Results: We found that the proliferation and osteogenic differentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion. Conclusion: Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration.

cell proliferation

osteogenic differentiation

mineralization

human mesenchymal stem cells

implantable materials

colloidal lithography

nanotopography

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Publicerad i

International journal of nanomedicine

1176-9114 (ISSN) 1178-2013 (eISSN)

Vol. 9Nummer/häfte 1s. 2499-2515

Kategorisering

Ämneskategorier

Biomaterialvetenskap

Identifikatorer

DOI

10.2147/ijn.s58805

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Senast uppdaterat

2023-03-21