Serum fatty acid profile does not reflect seafood intake in adolescents with atopic eczema.
Artikel i vetenskaplig tidskrift, 2014

AIM: Long-chain polyunsaturated fatty acids (LCPUFAs) are immunomodulatory, but their role in allergy development is controversial. We investigated whether proportions of LCPUFAs in serum phospholipids were related to allergic diagnosis, seafood intake and LCPUFA proportions in cord blood. METHODS: Serum was obtained from 148 birth cohort children at 13 years of age. Forty had atopic eczema, 53 had respiratory allergy, and 55 were nonallergic. Proportions of LCPUFAs were determined in serum phospholipids; cord blood from 128 of the individuals was previously analysed. Seafood intake was estimated using questionnaires. RESULTS: Allergic and nonallergic individuals did not differ significantly regarding individual LCPUFAs. However, arachidonic acid over docosahexaenoic acid (DHA) ratio was higher in allergic, compared with nonallergic, adolescents. In nonallergic individuals, LCPUFA proportions in cord serum and adolescent serum correlated weakly. In individuals with atopic eczema and respiratory allergy, these correlations were weak or absent. A moderate correlation between seafood intake and serum DHA was seen in nonallergic individuals and those with respiratory allergy, but not in those with atopic eczema. CONCLUSION: Serum LCPUFA pattern was similar in allergic and nonallergic adolescents. Fatty acid metabolism may be altered in atopic eczema subjects, suggested by poor correlations between fatty acid intake and serum levels.

Polyunsaturated fatty acids

Fatty acids

Atopic eczema

Allergy

Asthma

Författare

Malin Barman

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Livsmedelsvetenskap

Karin Jonsson

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Livsmedelsvetenskap

Anna Sandin

Umeå universitet

Agnes E Wold

Göteborgs universitet

Ann-Sofie Sandberg

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Livsmedelsvetenskap

Acta Paediatrica, International Journal of Paediatrics

0803-5253 (ISSN) 1651-2227 (eISSN)

Vol. 103 9 968-976

Ämneskategorier

Pediatrik

Immunologi inom det medicinska området

Kemi

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1111/apa.12690

PubMed

24837739

Mer information

Senast uppdaterat

2018-02-27