Bridging the gaps in systems biology
Reviewartikel, 2014

Systems biology aims at creating mathematical models, i.e., computational reconstructions of biological systems and processes that will result in a new level of understanding-the elucidation of the basic and presumably conserved "design" and "engineering" principles of biomolecular systems. Thus, systems biology will move biology from a phenomenological to a predictive science. Mathematical modeling of biological networks and processes has already greatly improved our understanding of many cellular processes. However, given the massive amount of qualitative and quantitative data currently produced and number of burning questions in health care and biotechnology needed to be solved is still in its early phases. The field requires novel approaches for abstraction, for modeling bioprocesses that follow different biochemical and biophysical rules, and for combining different modules into larger models that still allow realistic simulation with the computational power available today. We have identified and discussed currently most prominent problems in systems biology: (1) how to bridge different scales of modeling abstraction, (2) how to bridge the gap between topological and mechanistic modeling, and (3) how to bridge the wet and dry laboratory gap. The future success of systems biology largely depends on bridging the recognized gaps.

Systems biology


Model merging

Model standards

Sensitivity analysis


Marija Cvijovic

Göteborgs universitet

Chalmers, Matematiska vetenskaper, Matematik

Joachim Almquist

Chalmers, Kemi- och bioteknik, Livsvetenskaper

Jonas Hagmar

Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik

Stefan Hohmann

Göteborgs universitet

H. M. Kaltenbach

Eidgenössische Technische Hochschule Zürich (ETH)

Edda Klipp

Humboldt-Universität zu Berlin

Marcus Krantz

Humboldt-Universität zu Berlin

P. Mendes

University of Manchester

S. Nelander

Uppsala universitet

Jens B Nielsen

Chalmers, Kemi- och bioteknik, Livsvetenskaper

A. Pagnani

Politecnico di Torino

N. Przulj

Imperial College London

A. Raue

Albert-Ludwigs-Universität Freiburg

J. Stelling

Eidgenössische Technische Hochschule Zürich (ETH)

S. Stoma

Institut National de Recherche en Informatique et en Automatique (INRIA)

F. Tobin

Tobin Consulting LLC

J. A. H. Wodke

Humboldt-Universität zu Berlin

R. Zecchina

Politecnico di Torino

Mats Jirstrand

Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik

Molecular Genetics and Genomics

1617-4615 (ISSN) 1617-4623 (eISSN)

Vol. 289 5 727-734


Livsvetenskaper och teknik (2010-2018)


Bioinformatik och systembiologi



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