Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population
Artikel i vetenskaplig tidskrift, 2014
Genetic variants within the major histocompatibility complex (MHC) represent the strongest genetic susceptibility factors for primary sclerosing cholangitis (PSC). Identifying the causal variants within this genetic complex represents a major challenge due to strong linkage disequilibrium and an overall high physical density of candidate variants. We aimed to refine the MHC association in a geographically restricted PSC patient panel.
Författare
Sigrid Næss
Oslo universitetssykehus
Universitetet i Oslo
Benedicte A Lie
Oslo universitetssykehus
Espen Melum
Oslo universitetssykehus
Marita Olsson
Göteborgs universitet
Chalmers, Matematiska vetenskaper, Matematisk statistik
Johannes R Hov
Oslo universitetssykehus
Universitetet i Oslo
Peter J P Croucher
University of California
Jochen Hampe
Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus
Erik Thorsby
Oslo universitetssykehus
Universitetet i Oslo
Annika Bergquist
Karolinska universitetssjukhuset
James A Traherne
Cambridge Institute for Medical Research
University of Cambridge
Erik Schrumpf
Oslo universitetssykehus
Kirsten Muri Boberg
Universitetet i Oslo
Oslo universitetssykehus
Stefan Schreiber
Christian-Albrechts-Universität zu Kiel
Andre Franke
Christian-Albrechts-Universität zu Kiel
Tom H Karlsen
Oslo universitetssykehus
Universitetet i Oslo
PLoS ONE
1932-6203 (ISSN) 19326203 (eISSN)
Vol. 9 12 e114486- e114486Ämneskategorier
Biologiska vetenskaper
Genetik
Styrkeområden
Livsvetenskaper och teknik (2010-2018)
DOI
10.1371/journal.pone.0114486
PubMed
25521205