Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population
Artikel i vetenskaplig tidskrift, 2014

Genetic variants within the major histocompatibility complex (MHC) represent the strongest genetic susceptibility factors for primary sclerosing cholangitis (PSC). Identifying the causal variants within this genetic complex represents a major challenge due to strong linkage disequilibrium and an overall high physical density of candidate variants. We aimed to refine the MHC association in a geographically restricted PSC patient panel.

Författare

Sigrid Næss

Oslo University Hospital

Universitetet i Oslo

Benedicte A Lie

Oslo University Hospital

Espen Melum

Oslo University Hospital

Marita Olsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Johannes R Hov

Oslo University Hospital

Universitetet i Oslo

Peter J P Croucher

University of California

Jochen Hampe

Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus

Erik Thorsby

Oslo University Hospital

Universitetet i Oslo

Annika Bergquist

Karolinska universitetssjukhuset

James A Traherne

Cambridge Institute for Medical Research

University of Cambridge

Erik Schrumpf

Oslo University Hospital

Kirsten Muri Boberg

Universitetet i Oslo

Oslo University Hospital

Stefan Schreiber

Christian-Albrechts-Universität zu Kiel

Andre Franke

Christian-Albrechts-Universität zu Kiel

Tom H Karlsen

Oslo University Hospital

Universitetet i Oslo

PLoS ONE

1932-6203 (ISSN)

Vol. 9 e114486- e114486

Ämneskategorier

Biologiska vetenskaper

Genetik

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1371/journal.pone.0114486

PubMed

25521205