A Computational Investigation into the Effect of Infarction on Clinical Human Electrophysiology Biomarkers

Louie Cardone-Noott; Alfonso Bueno-Orovio; Ana Mincholé; Kevin Burrage; Mikael Wallman; Nejib Zemzemi; Erica Dall’Armellina; Blanca Rodriguez

A Computational Investigation into the Effect of Infarction on Clinical Human Electrophysiology Biomarkers
Paper i proceeding, 2014

The electrocardiogram (ECG) is often used to diag- nose myocardial infarction, but sensitivity and specificity are low. Here we present a computational framework for solving the bidomain equations over an image-based hu- man geometry and simulating the 12 lead ECG. First, we demonstrate this approach by evaluating a population of eight models with varying distributions of local action po- tential duration, and report that only the model with apico- basal and inter-ventricular heterogeneities produces con- cordant T waves. Second, we simulate the effects of an old anterior infarct, which causes a reduction in T wave amplitude and width. Our methodology can contribute to the understanding of ECG alterations under challenging conditions for clinical diagnosis.

Författare

Louie Cardone-Noott

University of Oxford

Alfonso Bueno-Orovio

University of Oxford

Ana Mincholé

University of Oxford

Kevin Burrage

University of Oxford

University of Queensland

Mikael Wallman

Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik

University of Oxford

Forskning Andra publikationer

Nejib Zemzemi

Institut National de Recherche en Informatique et en Automatique (INRIA)

Erica Dall’Armellina

John Radcliffe Hospital

University of Oxford

Blanca Rodriguez

University of Oxford

Proceedings of the 41st Computing in Cardiology Conference, CinC 2014, Cambridge, United States, 7-10 September 2014

2325-8861 (ISSN)

Vol. 41 673-676

Ämneskategorier

Beräkningsmatematik

Annan medicin och hälsovetenskap

Fundament

Grundläggande vetenskaper

Styrkeområden

Livsvetenskaper och teknik (2010-2018)

Mer information

Senast uppdaterat

2021-07-06

A Computational Investigation into the Effect of Infarction on Clinical Human Electrophysiology Biomarkers Paper i proceeding, 2014

Författare

Louie Cardone-Noott

Alfonso Bueno-Orovio

Ana Mincholé

Kevin Burrage

Mikael Wallman

Nejib Zemzemi

Erica Dall’Armellina

Blanca Rodriguez

Proceedings of the 41st Computing in Cardiology Conference, CinC 2014, Cambridge, United States, 7-10 September 2014

Ämneskategorier

Fundament

Styrkeområden

Mer information

Senast uppdaterat

A Computational Investigation into the Effect of Infarction on Clinical Human Electrophysiology Biomarkers
Paper i proceeding, 2014